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Yung Yi Hsiao, MS

Hsaio_Y PDDS24
Predoctoral Fellowship in Drug Discovery, 2024 University of California, Berkeley

Epigenetic Editing of Psychedelic-Induced Plasticity


Psychedelics are known to change the way the mind operates. Growing interest in the use of psychedelics in public health stems from clinical data showing a single dose of psychedelics being sufficient to drive immediate and enduring relief from neuropsychiatric disorders such as post-traumatic stress disorder (PTSD) and depression. Despite rising clinical interest, the molecular and cellular basis of psychedelic-induced plasticity remains unknown, where mechanistic insights into the transformative and long-lasting effects of psychedelics are necessary for its safe and effective use. Concurrently, advancement of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technologies opens up the possibility for programmable gene modulation in treatment of diseases. My goal is to combine the two rapidly developing fields of psychedelics and gene therapy to make CRISPR-based tools to target molecular pathways in treating defective plasticity in the brain.

It is an incredible honor to have been awarded the PhRMA Foundation Predoctoral Fellowship in Drug Discovery to support my research in the emerging field of psychedelic-inspired medicine. My goal is to not only understand the basic science behind psychedelic-induced plasticity, but to revolutionize the use of psychedelics as a therapeutic in treating defective plasticity in the brain.

Michael Hsiao

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