Question 1:
Plasma volume, total body water, cardiac output and renal glomerular filtration rate all go up in pregnancy by what percentage?
A. 10%
B. 20 – 30%
C. 30 – 50%
D. 50 – 70%
Question 2:
These increases (in plasma volume, total body water, cardiac output and GFR) peak early in the second trimester and then return to normal by delivery.
True or False?
Question 3:
Penicillins and cephalosporins are renally cleared, but the increases in both renal clearance and volume of distribution in pregnancy are not sufficient to support changes in dosing recommendations.
True or False?
Question 4:
Concentrations of albumin and α-1 acid glycoprotein go down in pregnancy. This means that there is less plasma protein to bind to medications and the unbound, free fractions of drugs go up.
True or False?
Question 5:
Because of these changes in protein binding, for some critical, highly protein-bound medications, it is important to measure the free fraction, not total drug, during pregnancy.
True or False?
Question 6:
P-glycoprotein in the placenta helps to protect the fetus by metabolizing medications that try to cross the placenta.
True or False?
Question 7:
The changes in reproductive hormones during pregnancy increase the activity of some Phase II hepatic metabolizing enzymes (conjugation/biotransformation).
True or False?
Question 8:
The changes in reproductive hormones during pregnancy have no effect on Phase I hepatic metabolism (chemical modification).
True or False?
Question 9:
Methadone clearance increases in pregnancy; therefore, pregnant women on methadone often require increases in their dose.
True or False?
Question 10:
Pharmacogenetic differences in drug metabolizing enzymes and drug transporters can affect how an individual person responds to medications during pregnancy.
True or False?
Presented by the PhRMA Foundation Safe and Effective Prescribing Project
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